OPTIMIZING THE CLINICAL IMPACT OF CAR-T CELL THERAPY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: LOOKING BACK WHILE MOVING FORWARD

Optimizing the Clinical Impact of CAR-T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia: Looking Back While Moving Forward

Chimeric antigen receptor T-cell (CAR-T) therapy has been successful Partitions in creating extraordinary clinical outcomes in the treatment of hematologic malignancies including relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL).With several FDA approvals, CAR-T therapy is recognized as an alternative treatment option for par

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Characteristics of urban network and city functions in the Yangtze River Delta Region: A multi-scale perspective

The development of cities and regions NITRO THCH MILK CHOCOLATE emerges from the complex associations at various spatial levels, highlighting the importance of a multi-scale approach to analyzing regional urban networks.This study attempts to establish a new analysis framework encompassing national, regional, and local dimensions by employing a pop

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PROK2 / PROKR2 signaling and Kallmann syndrome

Kallmann syndrome (KS) is a developmental disease that associates hypogonadism and a deficiency of the sense of smell.The reproductive phenotype of KS results from the primary interruption of the olfactory, vomeronasal and terminal nerve fibers in the frontonasal region, which in turn disrupts the embryonic migration of neuroendocrine gonadotropin-

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PASTRY: achieving balanced power for detecting risk and protective minor alleles in meta-analysis of association studies with overlapping subjects

Abstract Background Meta-analysis is a statistical method that combines the results of multiple studies to increase statistical power.When multiple studies participating in a meta-analysis utilize the same public dataset as controls, the summary statistics from these Stepping Stones studies become correlated.To solve this challenge, Lin and Sulliva

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